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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HINT1
All Species:
39.09
Human Site:
Y109
Identified Species:
66.15
UniProt:
P49773
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49773
NP_005331.1
126
13802
Y109
S
D
G
G
Q
S
V
Y
H
V
H
L
H
V
L
Chimpanzee
Pan troglodytes
XP_517911
93
10134
G84
H
V
H
L
H
V
L
G
G
R
Q
M
H
W
P
Rhesus Macaque
Macaca mulatta
XP_001099859
126
13755
Y109
S
D
G
G
Q
S
V
Y
H
V
H
L
H
V
L
Dog
Lupus familis
XP_531895
126
13718
Y109
S
D
G
G
Q
S
V
Y
H
V
H
L
H
V
L
Cat
Felis silvestris
Mouse
Mus musculus
P70349
126
13758
Y109
A
D
G
G
Q
S
V
Y
H
I
H
L
H
V
L
Rat
Rattus norvegicus
Q8K3P7
175
19675
S135
V
P
P
F
C
S
V
S
H
L
H
L
H
V
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_990020
126
13740
Y109
P
E
G
G
Q
S
V
Y
H
V
H
L
H
I
L
Frog
Xenopus laevis
NP_001087193
126
13657
Y109
P
D
G
G
Q
S
V
Y
H
L
H
L
H
V
F
Zebra Danio
Brachydanio rerio
Q5PNN8
160
18444
P116
V
P
P
Y
I
T
V
P
H
L
H
L
H
V
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_608711
150
16578
Y133
K
H
G
A
Q
S
V
Y
H
L
H
L
H
F
L
Honey Bee
Apis mellifera
XP_625049
204
22985
Y187
K
H
G
A
Q
S
V
Y
H
L
H
I
H
V
L
Nematode Worm
Caenorhab. elegans
P53795
130
14224
F113
K
D
G
A
Q
S
V
F
H
L
H
L
H
V
L
Sea Urchin
Strong. purpuratus
XP_001177228
128
13911
Y109
K
D
G
C
Q
S
V
Y
H
I
H
I
H
V
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P42856
128
14282
Y111
P
S
G
C
Q
S
V
Y
H
I
H
V
H
L
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
73.8
99.2
96.8
N.A.
94.4
20.5
N.A.
N.A.
82.5
78.5
22.5
N.A.
56
41.1
60
63.2
Protein Similarity:
100
73.8
99.2
98.4
N.A.
99.2
39.4
N.A.
N.A.
91.2
89.6
40.6
N.A.
69.3
50.9
73
75
P-Site Identity:
100
6.6
100
100
N.A.
86.6
46.6
N.A.
N.A.
80
80
46.6
N.A.
66.6
66.6
73.3
66.6
P-Site Similarity:
100
20
100
100
N.A.
100
60
N.A.
N.A.
93.3
86.6
60
N.A.
73.3
80
86.6
86.6
Percent
Protein Identity:
N.A.
51.5
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
72.6
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
60
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
80
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
22
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
15
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
50
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
8
0
0
0
8
0
0
0
0
0
8
8
% F
% Gly:
0
0
79
43
0
0
0
8
8
0
0
0
0
0
0
% G
% His:
8
15
8
0
8
0
0
0
93
0
93
0
100
0
0
% H
% Ile:
0
0
0
0
8
0
0
0
0
22
0
15
0
8
15
% I
% Lys:
29
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
8
0
0
8
0
0
43
0
72
0
8
72
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
22
15
15
0
0
0
0
8
0
0
0
0
0
0
8
% P
% Gln:
0
0
0
0
79
0
0
0
0
0
8
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% R
% Ser:
22
8
0
0
0
86
0
8
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% T
% Val:
15
8
0
0
0
8
93
0
0
29
0
8
0
72
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% W
% Tyr:
0
0
0
8
0
0
0
72
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _